I feel less fatigued, less hazy/faded, my vision has improved a little bit and it’s easier to write/read.
Mostly though, I feel stressed out. MXE was so great at making me feel serene and calm, like everything was just fine even if my life was a mess. It gave me more time to think and provided me with strange clarity and motivation. Since stopping, I’ve been feeling a bit more depressive than usual… quick to anxiety and rage. I’ve been having a lot of sensory issues lately too, when I was on it I wouldn’t feel a thing but now every feeling is back and tenfold. I’ve also been using other substances more than usual: dropped acid, getting drunk, thinking about using DXM again, and popping whatever pills happen to come my way.
I plan on using again because I do believe it works for me as an effective antidepressant and pain reliever, but I have decided to be more strict with my habits and not go so overboard with dose experimenting.
And 1 day.
I have never done them together, but I’ve read much online and there’s mixed views about the similarity and mixing of these two.
Obviously they are both dissociative drugs, with hallucinogenic effects. Methoxetamine is believed to be an NMDA antagonist and a dopamine reuptake inhibitor, similar to Ketamine in the Arylcyclohexylamines class of drugs. DXM, however, is an opioid analgesic (an isomer of an analog of Codeine) and in very high doses acts as an NMDA receptor antagonist (like MXE) but also as a serotonin reuptake inhibitor, sigma-1 receptor, and has affinity towards the µ-opioid receptor as well.
DXM is much stronger and frightening than MXE. Both can completley remove you from reality, take you to new worlds, and make your mind wander to the furthest depths of your psyche. However, DXM’s effects are definitely much more intense/confusing/intoxicating, whereas MXE is much more pleasant and floaty.
Here is more info on the aspects of a dissociative trip.
Taking MXE with DXM would only make the effects of the DXM feel stronger I think. For a single time trip, I’d make sure to dose it right, and absolutely do not do these two together unless you have experience separately with both. Personally, though, I would watch out for this combo because both DXM and MXE are hard on your kidneys, and I’m sure the combination of the two in a high dose or on a regular basis would kill your liver and depress/frazzle your CNS!
I assume the reason he retracted was lack of evidence, but it really doesn’t excuse the fact that the whole procedure is methodologically flawed. There’s is no question to me that dissociatives can cause brain damage if used excessively. Onley’s Lesions appear to NOT be the cause of DXM-related brain damage in primates. I believe it’s excitotoxicity causing the problem.
There is quite a bit of DXM health info here.
It should also be mentioned that the lesions are believed to be caused by all dissociatives (NMDAR’s) but in the trials DXM seems to be the favored drug. Why? What about all of those people who are chronic K-heads for years and step out of their addiction mentally unscathed?
Fact is that Onley’s lesions have only been observed in RATS (which have twice the metabolic rate of humans anyway) after dissociative drugs were injected DIRECTLY INTO THEIR BRAINS! They’ve never been seen in humans or monkeys that have been tested. Dissociatives can cause dysfunction from wearing down of receptors and transmitters, but I definitely don’t believe they cause irreversible brain lesions.
Erowid’s Onley’s Lesions page is really the definitive guide for most people on this subject. Notice, however, that it was written in 1998 whereas the studies discounting their existence in monkey and human subjects weren’t concluded until the mid 2000’s. Also, at the very top of the page it states that the author RETRACTED HIS STATEMENTS in 2004!
Well this weekend has sucked. Work was hell. My ankle hurts and I need a new bike. SO FUCKING TIRED.
It’s been 16 days without taking MXE.
I could really go for some drugs right now, though.
theonewithouteyebrows replied to your post: i’ve gone 10 days now without doing mxe. only…
Why are you needing/wanting to stay sober-ish?
My tolerance was building up from using it so often, and I’d end up using a whole lot just to achieve a high that was not really euphoric but actually bordering on psychotic from too high of a dose. Dissociative drugs, good shit.
i’ve gone 10 days now without doing mxe. only smoking weed, and i took some adderal to stay awake at work.
sober enough. giving it two weeks at least.
Name of Deceased:JACKSON Angela Mary
Narrative Verdict - The deceased died after obtaining and taking Phenazepam and Methadone both obtained illeagally in unknown quantities.Name of Deceased: PASCALL AnthonyNarrative Verdict - The deceased died after obtaining and taking Phenazepam and Methadone both obtained illeagally in unknown quantities.